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The detection of sentinel lymph nodes using Sentimag® is ultrasensitive – and as it is proximity-based, localising nodes is highly intuitive. The system is suitable for both pre- and post-incision use, and its sensitivity can be adjusted according to three levels from the front panel control. The Sentimag® instrument uses the principle of magnetic susceptometry and generates an alternating magnetic field which transiently magnetises the iron oxide particles in Sienna+®. The tiny magnetic signature generated by the Sienna+® particles is then detected by the Sentimag® probe.
Sentimag® / Sienna+® system - SYSMEX LIFE SCIENCES
Sentinel Lymph node status is one of the most important prognostic factors in many cancers and a key criterion for surgical and therapeutic decisions. Great importance is therefore attached to the reliable and accurate analysis of the lymph node tissue for detection of metastases. OSNA® – One Step Nucleic Acid Amplification – is a highly automated molecular assay. The reaction procedure is based on specific isothermal technology to amplify nucleic acid (RT-LAMP) and allows the detection of Cytokeratin 19 (CK19) mRNA expression. CK19 is an epithelial cell marker and is not normally present in lymph node tissue. The expression rate of CK19 mRNA correlates with the size of the metastatic foci.